Download Application of Hyperthermia in the Treatment of Cancer by S. B. Field (auth.), Dr. med. Dipl. biochem. Rolf D. Issels, PDF

By S. B. Field (auth.), Dr. med. Dipl. biochem. Rolf D. Issels, Prof. Dr. med. Wolfgang Wilmanns (eds.)

Physicians, biologists and physicists current their fresh paintings within the box of hyperthermia with reference to either its program and its mix with radiation and chemotherapy. present technical probabilities, scientific administration and significant features of its use for superficial and deep-seated tumors are mentioned. the most themes mentioned are: adjustments of metabolism and microcirculation less than warmth stipulations, the organic interplay of warmth with X-rays and several other chemotherapeutic brokers, and the latest medical info from diverse associations at the mixed program within the remedy of cancer.

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Radiat Res 95: 471-485 Mitchell lB, Russo A, Kinsella TJ, Glatstein E (1983) Glutathione elevation during thermotolerance induction and thermosensitization by glutathione depletion. Cancer Res 43: 987-991 26 S. Mirtsch et al. Streffer C, van Beuningen D, Zamboglou N (1979) Cell killing by hyperthermia and radiation in cancer therapy. In: Abe M, Sakamoto K, Philips TL (eds) Treatment of radioresistant cancers. Elsevier/North Holland, Amsterdam, pp 55-70 Tietze F (1969) Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues.

Mitchell et al. (1983) have reported the effects of elevated temperatures on the GSH levels in cells. Continuous heating or acute heat exposure resulted in a rapid elevation of cellular GSH content up to about twice that of the control values. However, the GSH content returned to normal values subsequently. We have studied the effect of hyperthermia on the GSH and GSSG levels of two melanomas (MeWo and Be 11) in vitro and in vivo. Since it has been shown that Be 11 cells are less radiosensitive than Me Wo cells, we also examined the combined effects of irradiation and hyperthermia on the Be 11 cell lines.

Strohmenger, and C. Streffer Institut fUr Medizinische Strahlenbiologie, Universitatsklinikum Essen, HufelandstraBe 55, 4300 Essen 1, FRG Introduction Glutathione (L-y-glutamyl-L-cysteinyl-glycine) is found in animal cells and also in most plants and bacteria. Its functions in various fields, such as radiation biology and cancer therapy, are presently the subject of extensive studies by several groups of researchers (Meister and Anderson 1983). Most cellular glutathione exists in the reduced thiol form (GSH), although various mixed disulfides, thioester and to a lesser extent glutathione disulfide (GSSG) contribute to the total cellular pool of glutathione.

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