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Extra resources for Alzheimer's and Parkinson's Diseases: Progress and New Perspectives: 8th International Conference Ad pd, Salzburg, March 2007: Abstracts (Neuro-Degenerative Diseases)
Kachergus , L. Warren , 1 3 3 3 S. Thomas , R. Amouri , S. Ben Yahmed , M. Kefi , 3 3 1 1 M. Zouari , S. A. Akkari , R. Elango , 1 1 1 1 R. Prinjha , L. Ragone , L. Middleton , R. Gibson , 2 3 M. Farrer , F. Hentati 1 Research and Development, GlaxoSmithKline, RTP, 2 Harlow, UK, Department of Neuroscience, Mayo Clinic, 3 Jacksonville, FL, USA, Department of Neurology, Institut National De Neurologie, Tunis, Tunisia Background: PTEN induced putative kinase 1 (PINK1) is one of several genes implicated in autosomal recessive forms of Parkinson’s disease (PD).
Results: Preliminary results on cerebral rat tissues show that PSEN1 is expressed throughout postnatal development, although mRNA levels in males appear to be lower than in females in all the brain districts, suggesting a different transcriptional regulation of these genes. d and adult). Conclusions: Our data seem to confirm the existence of a modulation in the expression of gamma-secretase and show for the first time dramatic differences, in PSEN1 expression, between males and females during brain ontogenesis.
The clinical disability was indicated by Unified Parkinson disease rating scale(UPDRS) part II & III. The parameters of PFT were not different between IPD and control group, and between non-smoker IPD and smoker IPD group. We use Speraman correlation test for statistic method. Results: There is no significant difference in the parameters of PFT between tremor dominant and postural instability and gait disturbance group. 05). 05). Conclusions: We conclude that less coordinated and less explosive muscle force contributes to the change of FEF75%, and suggest parameters of PFT may be used as indicators of severity of IPD.