By Felix R. Althaus, Hanna E. Kleczkowska (auth.), Rafael Alvarez-Gonzalez (eds.)
This particular factor of Molecular and mobile Biochemistry includes twenty-two chosen examine papers and studies from a complete of 1 hundred and ten displays given on the twelfth overseas Symposium on ADP-ribosylation Reactions: From Bacterial Pathogenesis to melanoma, held in Cancun, Mexico, may possibly 10-14, 1997. The Symposium used to be hosted by way of the Sociedad Mexicana de Bioquimica and was once backed by means of the college of North Texas overall healthiness technological know-how heart, citadel worthy, TX, united states.
This quantity offers a state of the art resource of knowledge for simple scientists and clinicians who're drawn to the molecular, biochemical, and mobile elements of protein-(ADP-ribose) move reactions in human healthiness and disease.
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Extra resources for ADP-Ribosylation Reactions: From Bacterial Pathogenesis to Cancer
A series of reports by Hall and colleagues have suggested that, at least in some fibroblast cell lines, each mammalian Rho family member regulates a specific type of actinbased cytoskeletal structure [7,23,24]: Rho - focal adhesions and stress fibers, Rac - lamellipodia and ruffling, and Cdc42 - filopodia. Based on these findings, a hierarchical model of activity for Rho GTPases has evolved (outlined in Fig. 3A) [2, 7, 23, 24]. In the last few years, though, it has become apparent that Rho family members also help modulate other cytoskeletal-dependent cellular functions, including cell-cell adhesion, cell spreading, cell motility, and cytokinesis [6, 7, 16, 25].
Chatterjee S, Cheng MF, Berger RB, Berger SJ, Berger NA: Effect of inhibitors of poly(ADP-ribose) polymerase on the induction of GRP78 and subsequent development of resistance to etoposide. Cancer Res 55: 868-873, 1995 12. Chatterjee S, Cheng MF, Berger SJ, Berger NA: Induction of M(r) 78,000 glucose-regulated stress protein in poly(adenosine diphosphateribose) polymerase- and nicotinamide adenine dinucleotide-deficient V79 cell lines and its relation to resistance to the topoisomerase II inhibitor etoposide.
Denhardt DT: Signal-transducing protein phosphorylation cascades mediated by RaslRho proteins in the mammalian cell: The potential for multiplex signaling. Biochem J 318: 797-747, 1996 14. Lim L, Manser E, Leung T, Hall C: Regulation of phosphorylation pathways by p21 OTPases. Eur J Biochem 242: 171-185, 1996 15. Schweins T, Wittinghofer A: Structures, interactions, and relationships. CUIT Bioi 4: 547-550,1994 16. Takai Y, Sasaki T, Tanaka K, Nakanishi H: Rho as a regulator of the cytoskeleton.