By Simone Giacopuzzi, Andrea Zanoni, Giovanni de Manzoni
This booklet deals up to date and entire assurance of the prognosis and remedy of adenocarcinoma of the esophagogastric junction (EGJ). As is acceptable within the period of multidisciplinary and multimodal remedy, the contributions of the entire numerous experts concerned cooperatively within the therapy of EGJ melanoma are completely defined. targeted realization is usually paid to the importance of preneoplastic lesions, akin to Barrett esophagus. the ultimate a part of the booklet represents a surgical atlas documenting the options utilized in the EGJ zone, with tremendous colour photos and stepwise description of techniques. opposed to the heritage of the speedily expanding occurrence in EGJ melanoma, particularly glaring in Western international locations, there's a want for larger uniformity in administration options, which presently differ considerably the world over. This ebook presents applicable counsel that may help all practitioners desirous about the prognosis and remedy of EGJ cancers, together with surgeons, oncologists, and radiotherapists.
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Additional resources for Adenocarcinoma of the Esophagogastric Junction: From Barrett's Esophagus to Cancer
Lim YC, Fitzgerald RC (2013) Diagnosis and treatment of Barrett’s oesophagus. Ishimura N, Amano Y et al (2011) Barrett’s esophagus: endoscopic diagnosis. Ann N Y Acad Sci 1232:53–75 41. Rees JR, Lao-Sirieix P, Wong A, Fitzgerald RC (2010) Treatment for Barrett’s oesophagus. 1 Introduction Since the recognition of Barrett’s esophagus as a precancerous condition, efforts have focused on its eradication. Aggressive acid suppression with medical or surgical anti-reflux therapy led to inconsistent results in regression of Barrett’s epithelium.
002) by comparison with NDBE . On multivariate analysis, LGD emerged as an independent risk factor for progression to HGD/EA . There are contrasting data in the literature on the incidence of LGD progression to EA, however. 4 months (3083 patient-years), performing a median of 3 endoscopies per patient. Patients with incident HGD and/or cancer were excluded. 01). 02) . The BEST (Barrett’s Esophagus Study) challenged this outcome on the grounds of a large database prospectively compiled by 5 high- volume centers.
In a study of 32 patients with HGD, 78 % had eradication of HGD and 69 % had eradication of Barrett’s. However, there was 13 % progression to EAC in a mean follow-up period of 34 months . Another potential role is in palliative treatment of advanced cancer causing dysphagia or bleeding . Complications include strictures, fever, bleeding, and, rarely, perforation. 7 MPEC Ablation of Barrett’s using multipolar electrocoagulation (MPEC) is a fairly simple technique. A 10 French MPEC probe is passed through a therapeutic endoscope, and thermal energy is applied at 15–20 W setting till a white coagulum appears.